A histamine H2 receptor antagonist
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Labeled Version(s)
22583Ranitidine-d6 (hydrochloride)
Metabolite(s)
35412Ranitidine S-oxide
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Product Type

Small Molecule Modulators
Receptor Pharmacology
Antagonists

Research Area

Ranitidine (hydrochloride)

Item No. 16939

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N'-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N-methyl-2-nitro-1,1-ethenediamine, monohydrochloride
CAS Number
66357-59-3
Molecular Formula
C13H22N4O3S • HCl
Formula Weight
350.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
230, 325 nm
SMILES
CN/C(NCCSCC1=CC=C(CN(C)C)O1)=C\[N+]([O-])=O.Cl
InChi Code
InChI=1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9+;
InChi Key
GGWBHVILAJZWKJ-KJEVSKRMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

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    Product Description

    Ranitidine is a histamine H2 receptor antagonist.1 It reverses histamine-induced relaxation of isolated rat uterine horn (pA2 = 6.9) as well as histamine-induced increases in contraction frequency in isolated guinea pig right atrium (pA2 = 7.2). Ranitidine (0.03-3 mg/kg, i.v.) inhibits histamine-and pentagastrin-induced gastric acid secretion in a dose-dependent manner in anesthetized rats. Formulations containing ranitidine have been used in the treatment and preventrion of heartburn and gastroesophageal reflux disease (GERD).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Daly, M.J., Humphray, J.M., and Stables, R. Some in vitro and in vivo actions of the new histamine H2-receptor antagonist, ranitidine. Br. J. Pharmacol. 72(1), 49-54 (1981).